Ear Infection Treatment Shouldn’t Be Shortened
Study confirms that the standard antibiotics prescribed for an ear infection need to be taken the full 10 days.
Middle ear infections are common in kids. The illness is often caused by bacteria, and can be treated with antibiotics. But bacteria can become resistant to antibiotics. That’s why it’s important to take these medications as directed.
Scientists have wondered if shorter treatments might reduce the risk of bacteria becoming resistant to antibiotics. Shorter treatments might also reduce other side effects. A new NIH-funded study provides some answers—at least for children under age 2.
The study enrolled 520 children, ages 6 to 23 months, who had middle-ear infections diagnosed using stringent criteria. Kids were randomly assigned to receive either a standard 10-day course of antibiotics or a shorter (5-day) treatment.
The scientists found that 77 of the 229 children (34%) in the 5-day treatment group did not improve or had worsening symptoms and signs of infection, compared to 39 of 238 (16%) who received the 10-day treatment.
After treatment, the researchers examined bacteria from the kids’ noses and throats. They’d expected the shorter treatment to reduce the development of drug-resistant bacteria. However, they found no significant differences between the 2 groups. Both treatment groups also had similar levels of side effects.
“The results of this study clearly show that for treating ear infections in children between 6 and 23 months of age, a 5-day course of antibiotic offers no benefit in terms of adverse events or antibiotic resistance,” says study lead Dr. Alejandro Hoberman of the University of Pittsburgh School of Medicine. The findings confirm that standard antibiotics prescribed for an ear infection should be taken the full 10 days in young children.
Shortened Antimicrobial Treatment for Acute Otitis Media in Young Children. Hoberman A, Paradise JL, Rockette HE, Kearney DH, Bhatnagar S, Shope TR, Martin JM, Kurs-Lasky M, Copelli SJ, Colborn DK, Block SL, Labella JJ, Lynch TG, Cohen NL, Haralam M, Pope MA, Nagg JP, Green MD, Shaikh N. N Engl J Med. 2016 Dec 22;375(25):2446-2456. doi: 10.1056/NEJMoa1606043. PMID: 28002709.
Funding: NIH’s National Institute of Allergy and Infectious Diseases (NIAID) and National Center for Advancing Translational Sciences (NCATS).